Abstract
One hundred and thirty six patients with primary breast cancer were microscopically examined by using factor VIII related antigen (FVIIIRAg) staining for studying the blood vessel invasion (BVI), and some correlations between BVI and pathologic factors or 5-year survival rate were discussed. H.E. and E.v.G. stainings were performed in all the patients and then the main lesions were stained with FVIIRAg. BVI was found in 20.6% or 33.8% of the subjects by E.v.G. or FVIIRAg staining respectively. The 5-year survival rate was 58.7% in FVIIIRAg-positive cases while 77.8% in FVIIIRAg-negative ones with a significant difference. When the modes of BVI were morphologically classified as thrombotic, floating, infiltrating and mixed types, prognosis in floating type was significantly poor. The frequency of BVI in papillotubular carcinomas was as significantly low as 18.2%. This might contribute to the good prognosis of papillotubular carcinoma. Fourty-three point nine percent of patients with lymph node metastasis had BVI while 24.3% of patients without lymph node metastasis even showed evidence of invasion of the blood veseels. The presence of BVI in patients without lymph node metastasis may explain a possible occurrence of disseminated disease.
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