Abstract
AbstractThe permeabilities of low molecular weight metabolites were determined through chitosan and a series of chitosan—poly(vinyl pyrrolidone) (PVP) membranes. The dialysis studies were carried out in vitro using a diaphragm‐type test cell. The basic metabolites (urea, creatinine, and glucose) show higher permeation rates than do the acidic metabolites (uric acid and phosphate) through all the modified membranes. The hydrophilicity of the membranes, molecular weight, and chemical nature of the metabolites were important parameters in determining transport properties of the membranes. It was observed that higher permeation rates can be obtained by manipulating the amount of PVP in the blended membranes. The PVP weight loss in the aqueous medium was negligible.
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