Studies on Fluid bed Granulation of Lactose-MCC mixture

Abstract

This work is aimed to study the effect of various processes and design parameters viz., binder concentration, binder composition, spray rate and spray gun location on the granule and tablet attributes of Lactose-MCC mixture employing a process intensified fluid bed granulator. Experiments were designed so as to understand the complex interplay of various parameters at micro level on different attributes like attrition strength, Carr’s index, Hausner ratio, Granule Size distribution etc. The effect of viscosity and droplet size of the binder estimated using well established models was studied on the above said attributes. The results achieved were interesting that point new directions to granulation research.