Studies on congenital rubella. Preliminary results on the frequency and significance of presence of rubella virus in the newborn and the effect of gamma-globulin in preventing congenital rubella.

Abstract

IN 1941, Gregg1pointed out the existence of congenitally acquired rubella. There have since been many investigations into this problem in an effort to determine its scope, to define the teratogenic mechanisms, and to devise methods to prevent it. Today, 25 years later, we have available the necessary laboratory tools to seek answers in a more definitive manner.2,3The epidemic which occurred in Cincinnati and Dayton, Ohio, in the spring of 1964 provided an opportunity to study some aspects of congenital rubella. This report will present preliminary findings. Materials and Methods The 1,549 infants born at the Cincinnati General Hospital from Oct 15, 1964, to April 1, 1965, were studied. Cord bloods for antibody determination were obtained at delivery. The infants were examined and a pharyngeal swab for viral study was taken within 12 hours of birth. All infants were reexamined at least once before their hospital discharge.