Studies on Cashew and Shrimp-Oral Immunotherapy-Induced Changes in Allergen-Reactive CD4+ T Cells

Abstract

Oral Immunotherapy (OIT) is a promising intervention for food allergic individuals and has been FDA-approved to treat peanut allergy. Various hitherto studies have probed the clinical efficacy and immune mechanism of OIT-induced desensitization to peanut, milk, and egg, although immunomodulatory effects of cashew and shrimp-OIT have not been investigated. Thus, we examined pre- vs. post-OIT PBMCs from 38 cashew (n=33) or shrimp (n=5) OIT treated participants.