Abstract
Some novel compounds having a fluoromethyl group at the C7-position on 1-alkyl-1, 4-dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acid and on 1-alkyl-1, 4-dihydro-4-oxo-quinoline-3-carboxylic acid were prepared and their antibacterial activities were examined in vitro. In a series of quinolines, no striking difference of antibacterial activities between the 7-fluoromethyl and 7-methyl derivatives was observed. However, the activity was increased in the series of 1, 8-naphthyridines by replacement of the methyl group with the fluoromethyl group. As regards the N1-substituents, the 2-fluoroethyl compound showed a higher activity than the others.
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