Abstract
Antibacterial activity against Shigella flexneri 2a and Salmonella typhi H 901 W was tested by the serial dilution method with 51 kinds of quinaldine series compounds (I) prepared from 2-acetyl-γ-butyrolactone, 2, 3-dihydro-4-methyl-1H-pyrrolo[3, 2-c]-quinoline series, 2, 3-dihydro-4-methylfuro[3, 2-c]quinoline series, and 2, 3-dihydro-1H-cyclopenta[b]quinoline series. The compounds possessing strong activity against typhoid bacilli all possess hydroxyl in the 8-position of quinoline ring and the ability to form chelation, as oxine, was thought to be the main cause of antibacterial activity.
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