Abstract
Effects of surface active agents (ionic and nonionic) on intestinal absorption of drugs were studied on three method, i. e., (1) circulation with surfactants, (2) preperfusion with surfactant solutions, followed by circulation of drug solution free from surfactants, and (3) feeding experiments of surfactants solutions, followed by circulation of drug solution. Effects of surfactants were reviewed from two points. One is the effect due to interaction of drugs with surfactants and the other effect due to degeneration of the intestinal mucosa. It is concluded that the absorption of ionized species of drugs were more decreased than that of unionized species in degenerated intestinal mucosa, except for ionic interaction between drugs and surfactants.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
