Abstract
Glomerulosclerosis was found in 47% of 64 nonobese genetically “diabetic” KK mice. The changes consisted of a progressive increase in mesangial matrix and cells forming diffuse lesions. Nodular-type lesions, made up of mesangial matrix and cells were also noted, and there were many so-called exudative lesions. The incidence of these lesions increased significantly with age. Lesions of blood vessels, interstitial tissue and tubules were not significant. — Gangrene of the extremities was found thus far in 4 KK mice. — Tolerance to oral glucose was impaired in a very high percentage of animals. Glycosuria was found mostly during the OGTT. In a significant percentage of animals serum fasting triglyceride values were high. Pancreatic immunoreactive insulin was about double and serum IRI three times higher in the KK mice. Elevated BUN levels and significant proteinuria were found in some of the KK mice.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
