IgA Nephropathy

Abstract

The AJKD Atlas of Renal Pathology presents a compilation of figures on a specific pathologic entity. You may download the figures to create your own personal, non-commercial library of images or to create slides for teaching purposes. The AJKD Atlas of Renal Pathology presents a compilation of figures on a specific pathologic entity. You may download the figures to create your own personal, non-commercial library of images or to create slides for teaching purposes. Fig 1BIgA nephropathy with minimal increase in mesangial matrix and cells (normal is less than or equal to 3 cells/mesangial area). The diagnosis must rely on additional immunofluorescence and electron microscopic studies ([A] periodic acid-Schiff, original magnification ×200; [B] Jones' silver stain, original magnification ×400).View Large Image Figure ViewerDownload Hi-res image Download (PPT)Fig 2Moderate diffuse mesangial expansion with increased matrix and cellularity in IgA nephropathy (Jones' silver stain, original magnification ×100).View Large Image Figure ViewerDownload Hi-res image Download (PPT)Fig 3AIgA nephropathy with moderate mesangial expansion with increased matrix and cells ([A] periodic acid-Schiff; [B] Jones' silver stain; original magnification for each ×200).View Large Image Figure ViewerDownload Hi-res image Download (PPT)Fig 3BIgA nephropathy with moderate mesangial expansion with increased matrix and cells ([A] periodic acid-Schiff; [B] Jones' silver stain; original magnification for each ×200).View Large Image Figure ViewerDownload Hi-res image Download (PPT)Fig 4Increased mesangial cellularity and matrix in IgA nephropathy (Jones' silver stain, original magnification ×400).View Large Image Figure ViewerDownload Hi-res image Download (PPT)Fig 5AIgA nephropathy may have superimposed segmental sclerosis in addition to variable mesangial increase. (A) A small peripheral sclerotic lesion with adhesion is present; (B) more advanced segmental sclerosis is shown ([A] Jones' silver stain; [B] periodic acid-Schiff; original magnification for each ×200).View Large Image Figure ViewerDownload Hi-res image Download (PPT)Fig 5BIgA nephropathy may have superimposed segmental sclerosis in addition to variable mesangial increase. (A) A small peripheral sclerotic lesion with adhesion is present; (B) more advanced segmental sclerosis is shown ([A] Jones' silver stain; [B] periodic acid-Schiff; original magnification for each ×200).View Large Image Figure ViewerDownload Hi-res image Download (PPT)Fig 6The diagnosis of IgA nephropathy rests on the finding of dominant or codominant IgA mesangial deposits, as shown here. Staining may also be present for IgG and IgM, but not in greater intensity than for IgA. C3 is also often present in the mesangial areas, usually equal to or less than IgA staining (anti-IgA immunofluorescence, original magnification ×200).View Large Image Figure ViewerDownload Hi-res image Download (PPT)Fig 7Henoch-Schönlein purpura (HSP) also has mesangial IgA deposits, and thus it appears morphologically like IgA nephropathy. Clinicopathological correlation is required to distinguish HSP from IgA nephropathy, but crescents, shown here, are more frequent in biopsied HSP than in IgA nephropathy (Jones's silver stain, original magnification ×100).View Large Image Figure ViewerDownload Hi-res image Download (PPT)Fig 8Mesangial electron dense deposits and increased mesangial matrix and cellularity in IgA nephropathy (transmission electron microscopy, original magnification ×4,500).View Large Image Figure ViewerDownload Hi-res image Download (PPT)Fig 9Mesangial electron dense deposits and increased mesangial matrix and cellularity in IgA nephropathy (transmission electron microscopy, original magnification ×8,500).View Large Image Figure ViewerDownload Hi-res image Download (PPT)Fig 10Marked increase in mesangial cellularity and matrix with massive mesangial dense deposits, with some extension of deposits to paramesangial areas. (Left) There is also interposition of cells in the glomerular basement membrane with new basement membrane formation on the endothelial aspect of the interposed cells (transmission electron microscopy, original magnification ×4,800).View Large Image Figure ViewerDownload Hi-res image Download (PPT)