Studies of urinary corticosteroid by a method permitting analysis of steroids poorly soluble in water. I. Normal adrenal function.

Abstract

Listen

Translate article

A METHOD for determination of urinary corticosteroid permitting estimation of those steroids poorly soluble in water as well as those which are freely soluble in water has been described (1). The corticosteroid estimated by this method has been termed the “total corticosteroid.” At times the steroids which partition from benzene to water have also been determined. The material which partitions freely from benzene into water is called the “water soluble corticosteroid.” The material which remains in the benzene fraction is called the “corticosteroid poorly soluble in water.” The excretion of the materials by subjects with normal adrenal function has been described (1). The present report concerns the excretion of these materials by patients with adrenal insufficiency. METHODS The methods of uring collection and analysis have been previously described (1). Results Total corticosteroid excretion Eleven patients with adrenal insufficiency have been studied. Single or infrequent cortiscosteroid measurements we...