Abstract
Twelve compounds, composed of C18, C19 and C21 steroids, were studied for their effect upon the differentiation of the secondary sexual structures in female rat fetuses. It was shown that androgens, estrogens and steroids with anti-estrogenic activity behave differently. Compounds with androgenic and/or estrogenic side-effects behave partly as androgens and/or as estrogens; as, for example, C17-alkylated derivatives of 19-nortestosterone. Changes induced by pregnane derivatives are related to the antiestrogenic potency of the steroid. Substitutionfor the neutralized endogenous estrogen by exogenous estradiol prevents the changes caused by steroids with the anti-estrogenic activity. Thus, the combination of MAP with estradiol inhibited completely changes usually observed in female rat fetuses when MAP is given alone. Alterations induced by TP are only partly inhibited by the administration of estradiol. The classification of steroids according to their principal effects and by their antihormonal properties...
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call