Abstract
Mixed amino-alkylamide chemically bonded phases have been prepared via two-step reaction which involved the initial modification of silica with aminopropyldimethylsilyl groups under environmentally sealed conditions followed by a secondary derivatization with different acid chlorides ( i.e., acetyl, hexanoyl and stearoyl chlorides). In addition, for comparative purposes two conventional C 18 phases with different coverage densities have been prepared. Subsequently, the physical properties of the mixed phases have been studied by liquid chromatography as well as by elemental analysis and solid-state nuclear magnetic resonance spectrometry. The resulting data have provided information about how the hydrophobic chains and the specific interaction sites in the bonded phases influence solute retention under reversed-phase conditions. A potentially important application of the mixed amino-alkylamide materials is for separating basic compounds such as amines and amides.
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