Abstract
Recent studies1-5 have demonstrated that a number of human adenoviruses are capable of forming intergeneric or transcapsidants,j with SV40 genetic material when propagated in monkey kidney cells naturally or deliberately contaminated with SV40. Such hybrids were recognized by their ability to induce SV40 T antigen detectable by complemenlt fixation (CF) and immunofluorescent (FA) techniques, and in some cases by induction of tumors having the cytologic and antigeinic characteristics of those induced by SV40 virus. The infectious SV40 was eliminated from one of these adenovirus-SV40 (Ad.-SV40) hybrids, the LL (E46) strain, by two serial passages with SV40 antiserum; this strain appears to carry only a portion of the SV40 genome. However, a number of the other hybrid strains conitained inifectious SV40 after 4-10 serial passages with SV40 antiseruM4' 5 7; and heat inactivation, serologic, and virus cloning studies7' 8 on the hybrid type 4 strain R.N.4 suggested that the persistence of SV40 was due to incorporation of the complete SV40 genome into adenovirus capsids. This report presents further evidence for this phenomenon, using the monlkey kidney-adapted adenovirus type 2 (Ad. 2) vaccine strain Ind. 2.4
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