Abstract
The adenovirus-SV40 hybrid viruses have been utilized for in vitro transformation experiments in order to answer the following questions: 1) Do all hybrids have the ability to transform primary weanling hamster kidney tissue culture cells? 2) What contribution to the transformation does the SV40 genome make, and would the effect on differentiation of hamster kidney cells observed with SV40 virus be seen by the hybrid viruses which contain only a portion of the SV40 genome? 3) What other markers of the SV40 genome are present in transformed cells other than the SV40 tumor (T) antigen? 4) Can a non-oncogenic adenovirus become oncogenic by the presence of a portion of the SV40 genome integrated with the adenovirus DNA? 5) Can enhancement of the oncogenic potential of an adenovirus be effected by the integration of a part of the SV40 genome? 6) If non-oncogenic adenoviruses, by hybridization, become oncogenic, would the tumors have a T antigen charactetristic of the non-oncogenic adenovirus? 7) What contributions to the transformation do the adeno and SV40 genomes make as regards morphology of the transformed cells?
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