Abstract
There is a significant correlation between intrinsic factor (IF) and HCI content in 2-hour gastric aspirates after maximal stimulation with betazole. This correlation is due only in part to the fact that IF and HCI values from each subject are derived from the same volumes of gastric juice. There is an exception to this correlation among acid hypersecretors; their IF output is elevated to a lesser order of magnitude. Mean IF secretion by groups of elderly subjects is less than mean IF secretion by groups of younger subjects. However, an analysis of individual results shows that some elderly males can secrete as much IF as younger men. This suggests that reduced IF secretion is not an inevitable consequence of senescence. Preliminary evidence is presented which suggests that vagotomy may reduce betazole-stimulated IF secretion in most patients by a comparable amount as it reduces HCI secretion; IF secretion is not reduced in a minority of patients.
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