Studies in the relationship between molecular structure and chromatographic behaviour : XI. The behaviour os some halogenated phenols and some halogeno-; alkyl-substituted phenols on cellulose—polyamide thin layers

Abstract

Sixty halogenated phenols and halogeno-; alkyl-substituted phenols have been chromatographed on thin layers of cellulose impregnated with polyamide (Nylon 66), in a non-aqueous eluent and in an aqueous eluent. The order of migration of the compounds is related to the site of solvation of the molecule by the mobile phase. The solvation site being the hydrophobic part of the molecule for the non-aqueous eluent and the phenolic group for the aqueous eluent. Steric effects appear to play a greater part in the migration of the compounds than do electronic effects; though the latter do contribute to the system. The position of substituents in the molecule and also the nature of the substituents are also shown to affect the R F values.