Abstract
1. 1. By means of the reverse passive transfer technique it was not possible to demonstrate the absorption of free ragweed antigen from the site of injection of alum-precipitated pyridine-ragweed complex (APPR) in nonatopic subjects. 2. 2. Direct skin tests with a strong ragweed extract in subjects injected with APPR failed to reveal induced sensitivity to ragweed antigen, as evidenced by the absence of delayed or immediate skin reactions. 3. 3. Direct tests on specific ragweed serum-sensitized sites with APPR were negative, whereas tests with aqueous ragweed extract in comparable concentrations were strongly positive. 4. 4. Skin sites in nonatopic subjects sensitized with a potent ragweed reagin-containing serum failed to detect free ragweed antigen following the injection with APPR.
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