Abstract
Direct skin tests and passive transfer tests were compared as to their abilities to detect skin-sensitizing antibody (SSA) to penicillin haptens in man. Direct skin tests were found to be a generally more sensitive detector of SSA. However, in some cases where penicillin therapy had been given recently, and the immune response to penicillin was still evolving, direct skin tests were negative in the face of positive passive transfer tests of the same specificity.
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