Stryphnodendron rotundifolium Mart. bark: Antiedematogenic and antinociceptive activity

Abstract

Background: Stryphnodendron rotundifolium Mart., known as “barbatimão” in folk medicine, it's used as an astringent, antiseptic, diuretic, cicatrizing, and intestinal deseases as leukorrhea and diarrhea. Objective: Then, this purpose of this research is to evaluate the antiedematogenic and antinociceptive activity of the S. rotundifolium bark hydroalcoholic extract (EHSR). Methods: For this, the animal model the acute ear edema induced by 10% phenol, capsaicin, histamine, croton oil by single and multiple applications and, abdominal contortions by acetic acid and hot plate models were assayed. Results: The EHSR (10 mg/mL) presented significant topical antiedematogenic activity when reducing ear edema following single (35.12%) and multiple croton oil applications on days 6, 7, 8 and 9 with a 34.60, 31.08, 31.69 and 27.90% reduction in ear thickness, respectively, and reducing masses by 29.8%. The EHSR also reduced phenol (40.55%) and histamine (64.87%) induced edema. The EHSR (100 mg/kg) demonstrated antinociceptive activity by significantly reducing the number of contortions (59.5%) and increasing the animal's time of permanence on the plate by 41.9% (T:90min). Conclusion: We conclude, therefore, that the S. rotundifolium hydroalcoholic extract possesses antiedematogenic and central and peripheral influence in antinociceptive action. Therefore, given the results presented herein, we suggest new in vivo assays be performed to evaluate the possible mechanism of actions involved in these activities.