Abstract
Background: Although animal models are powerful tools for understanding the mechanism of depression, there are limitations that make it difficult to translate the results obtained in preclinical studies. Methods: Male and female mice (n = 12/group) were submitted to the forced swimming and splash tests. Results: There was no difference between the immobility time of females and male animals in the forced swimming test. In the splash test, females showed lower latency for the first grooming behaviour and lower grooming time when compared to male animals. Conclusions: The findings indicate that male and female Swiss mice may exhibit different behaviours in experi- mental models of depression. However, due to the variation in protocols between laboratories, the results cannot be considered conclusive.
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