Abstract

Contraction of the heart is driven by cyclic interactions between the thick and thin filament proteins, mediated by Ca2+ level fluctuations. Recent advances in electron microscopy (EM) and molecular dynamics studies have provided structural understanding of the cardiac thin filament (cTF). However, for certain cTF-domains the structure and precise nature of protein-protein interactions remain unknown. One such region is the extended cardiac troponin t (cTnT) linker between TNT1 and TNT2, which remains structurally undefined due to its flexibility.

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