Challenges in Skeletal Muscle Physiology

Peter J Reiser

doi:10.3389/fphys.2010.00151

Abstract

Challenges in Skeletal Muscle Physiology

Highlights

Major gaps exist in our understanding of fundamental mechanisms underlying contraction, as well as of mechanisms that contribute to the control of muscle physiological properties
Evidence has accrued to support a role for an interaction between myosin binding protein-C (MyBP-C) and myosin in modulating skeletal and cardiac muscle contraction (e.g., Hofmann et al, 1991a,b; Luther et al, 2008)
It has been reported that interactions of MyBP-C with actin could have a modulatory role in contraction in cardiac muscle (Shaffer et al, 2009; Shchepkin et al, 2010) and this raises the possibility of a related mechanism in skeletal muscle

Summary

Introduction

Major gaps exist in our understanding of fundamental mechanisms underlying contraction, as well as of mechanisms that contribute to the control of muscle physiological properties. Evidence has accrued to support a role for an interaction between MyBP-C and myosin in modulating skeletal and cardiac muscle contraction (e.g., Hofmann et al, 1991a,b; Luther et al, 2008).

Results

Conclusion