Abstract
Alkaline borohydride reductive cleavage of the mucin, purified from gastric aspirates of the secretors with blood group A, resulted in a heterogeneous population of neutral (79.7%) and acidic (20.3%) oligosaccharide alditols. Nine oligosaccharides (I-IX), ranging from 6 to 15 sugar units, have been purified from the neutral oligosaccharide fraction. Based on the results of immunological assays, sugar composition, degradation with specific exoglycosidases, and methylation analyses, we propose the following structures for these oligosaccharides: (sequence in text)
Highlights
21684-07from the National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, United States Public Health Service
Theadherentlayer of mucuswhichcovers thegastric epithelium is a heterogeneous mixture of the molecules which find their way into the mucosal surface either by process of must be hereby marked “Oduertkement” in accordance with 18 U.S.C
Thisviscous layer accounted for 78.2% of the neutral oligosaccharide fraction consists of proteins, glycoproteins, and lipids imbibed with and ranged from6 to 15 sugar units in length
Summary
The physiological importance of variations in carbohydrate chains of mucins is far from being well understood, it is generally accepted that this feature allows for each mucin an infinite number of distinct biological functions. 62% of the total carbohydrate chain of mucin, were purified drate chains, this C-6 substituentmay be a single residue of from the neutral oligosaccharide fraction. These compounds galactose or N-acetylglucosamine, or it may consist of blood. Possess the structureshomologous to neutraloligosaccharides described here and elsewhere [18].Only will we be able to fully ascertain how thestructural heterogeneity inthe carbohydrate chains of gastric mucin is translated into its biological functions towhich this mucin is destined
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