Abstract
Objective To explore the correlations between retinal nerve fiber layer (RNFL) thickness measured with spectral domain optical coherence tomography (OCT) and visual field light sensitivity in POAG and CPACG.Methods Twenty-two patients (22 eyes) with POAG and 22 patients (22 eyes) with CPACG were examined by using RTV100-2OCT and OCTOPUS101 visual field analyzer.The RNFL thickness and visual field light sensitivity in the two groups of patients were compared.Correlations between RNFL thickness and visual field light sensitivity were determined by Pearson product moment correlation analysis.Results In POAG group,the average RNFL thickness,superior average RNFL thickness and inferior average RNFL thickness were (91.19±15.85)μm,(94.93±18.76)μm,(87.82±15.65)μm,respectively; in CPACG group,the corresponding RNFL thickness were (88.22 ± 13.01)μm,(90.41 ± 14.16)μm,(86.49 ± 16.63)μm,respectively; differences of RNFL parameters was not significant between POAG group and CPACG group (P ＞0.05).In POAG group,mean sensitivity (MS),superior hemi-visual field average sensitivity and inferior hemi-visual field average sensitivity were (19.80±6.22)dB,(18.64±6.23)dB,(20.87±6.46)dB,respectively; in CPACG group,the corresponding sensitivity were (16.36±3.87)dB,(15.62±4.95)dB,(17.19±5.76)dB,respectively; differences of MS was significant between POAG group and CPACG group (P ＜0.05),differences of superior and inferior hemi-visual field average sensitivity was not significant between POAG group and CPACG group (P ＞0.05).In POAG group,average RNFL thickness,superior and inferior average RNFL thickness were correlated with average sensitivity of the corresponding visual field with the significant correlation coefficient 0.619,0.562,0.577,respectively (P ＜0.01); in CPACG group,average RNFL thickness,superior and inferior average RNFL thickness were correlated with average sensitivity of the corresponding visual field with the significant correlation coefficient 0.822,0.872,0.802,respectively (P ＜0.01).The differences of correlation coefficient between average RNFL thickness,inferior average RNFL thickness with average sensitivity of the corresponding visual field was not significant in the two groups (P ＞0.05).The differences of correlation coefficient between superior average RNFL thickness with inferior hemi-visual field average sensitivity was significant in the two groups (P ＜0.05).Conclusions POAG eyes have moderate positive structure-function correlations.CPACG eyes have high positive structure-function correlations.Compared with POAG eyes,CPACG has better correlations between superior average RNFL thickness and inferior hemi-visual field average sensitivity. Key words: Optical coherence tomography; Glaucoma; Structure; Function; Correlation
Published Version
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