Abstract
Mature parenchymal hepatocytes in the normal intact liver are in the quiescent GO phase and their proliferative potential is highly suppressed. However, once the liver is subjected to insult, such as partial hepatectomy or hepatitis, hepatocytes actively proliferate and liver regeneration occurs. Proliferation of hepatocyte in liver regeneration is regulated by both the cytosocial environment through cell-cell and cell-matrix interactions and by the action of humoral factor. Hepatocyte growth factor (HGF) was originally identified as a potent mitogen for mature hepatocytes in primary culture in serum of partially hepatectomized rat and rat platelets (Nakamura et al.,1984; Russel et al., 1984). HGF was first purified to homogeneity from rat platelets (Nakamura et al., 1986; Nakamura et al., 1987), thereafter from human plasma (Gohda et al.,1988), rabbit plasma (Zarnegar and Michalopoulos, 1989), and livers of CCl4-treated rats (Asami et al., 1991). In 1989, both human and rat HGF cDNAs were cloned and this factor was proved to be a novel one distinct from other known factors (Nakamura et al.,1989; Miyazawa et al., 1989;Tashiro et al,1990).
Published Version
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