Abstract
Structure of Signaling Enzyme Reveals How Calcium Turns It On
Highlights
Calcium signaling is central to many of the most important cellular processes, from intracellular transport to memory
Though extremely short-lived, these calcium spikes lead to the activation of the enzyme calcium/calmodulin-dependent kinase II (CaMKII)
Despite the importance of CaMKII activation, a complete understanding of the mechanism underlying it has been elusive, largely because the structure of the catalytic and regulatory domains in complex with Ca2+/CaM has not been resolved. In this issue of PLoS Biology, Peter Rellos, Stefan Knapp, and colleagues determine the enzyme’s structure in its activated form, revealing the molecular events that switch on catalytic CaMKII activity in the presence of calcium
Summary
Calcium signaling is central to many of the most important cellular processes, from intracellular transport to memory. Structure of Signaling Enzyme Reveals How Calcium Turns It On Calmodulin ( called Ca2+/CaM) can bind to a large variety of cellular targets, altering their structure and their function.
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