Abstract
A novel bi-modal imaging contrast agent was fabricated by depositing a layer of CdTe on the surface of CoFe2O4 nanoparticle, and applications for optical-MRI bi-modal imaging were investigated. The core/shell structure of the obtained nanocomposite was verified by TEM. TGA and nuclear magnetic relaxation dispersion (NMRD) profiles were applied for the deposition study. The in-vivo and in-vitro results showed that the deposition of CdTe layer can evidently improve the relaxivity of CoFe2O4 nanoparticle, which was investigated and explained by a “cation migration” theory. The as-synthesized compound is a promising nanocomposite for high performance bi-modal imaging applications.
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