Structure, characteristics and abilities to predict regional drug resistance of Mycobacterium tuberculosis in a therapeutic facility of Federal Penitentiary Service of Russia

Abstract

The aim of this retrospective single-center continuous study was to investigate structure, characteristics and abilities to predict regional drug resistance of Mycobacterium tuberculosis in a therapeutic facility of Federal Penitentiary Service of Russia. Methods . Sputum samples of all patients with newly diagnosed, recurrent or previously treated tuberculosis admitted to a tuberculosis hospital in 2007 – 2015 were cultured. Results. Data on structure and changes in primary (PDR), multiple (MDR) and broad-spectrum (BSDR) drug resistance of Mycobacterium tuberculosis in newly diagnosed tuberculosis patients, secondary (SDR), MDR and BSDR of Mycobacterium tuberculosis in patients with recurrent tuberculosis are presented in the article. Proportion of newly diagnosed tuberculosis patients with drug resistance increased from 50.7% to 72.9%. MDR increased from 12.1% to 40.4%, and BSDR increased from 1.3% to 11.4% in this group of patients. Proportion of patients with recurrent tuberculosis and with drug resistance increased from 54.5% to 100%. In these patients, MDR increased from 41.7% to 81.3%, and BSDR increased from 4.3% to 41.7%. In patients with previously treated tuberculosis, SDR increased from 79.3% to 96.8%, MDR increased from 31.1% to 76.8%, and SBDR increased from 5.9% to 39.7%. Conclusion . A high level of PDR, growth of MDR and gradual increase in BSDR are expected. An explanation of this process is long-term treatment of chronic tuberculosis in penitentiary service that facilitates development of consistent population of Mycobacterium tuberculosis with significant drug resistance.