Primary drug resistance of mycobacterium tuberculosis in HIV-positive patients

Abstract

Primary drug resistance (PDR) of Mycobacterium tuberculosis is detected in more than 34,5% new cases in Belarus and the portion increases annually. Gomel region has the highest level of HIV associated tuberculosis (TB) in Belarus (about 5,4% of new cases). The aim of study was to investigate PDR incidence and spectrum in HIV-positive patients in comparison with HIV-negative ones. We investigated 100 HIV-positive and 133 HIV-negative new TB cases. The groups were statistically equal by gender and age. PDR was detected by MBT cultivation on Loewenstein-Jensen medium. The results of study are represented in the table: Neither PDR proportion no PDR spectrum reliable difference was found in groups of HIV-positive and HIV-negative patients. HIV-positivity was not concluded to be a reliable risk factor of PDR occurrence and didn9t influence PDR spectrum.