Structure-based optimization of indoline-containing compounds as second generation inhibitors of NF-κB-inducing kinase (NIK)

Jing Cheng,Ziqin Yan,Xinzhi Li,Chen Liu,Linjiang Tong,Xilin Lyu,Bingjie Yang,Zheng Chen,Yujun Zhao

doi:10.1016/j.molstruc.2023.136755

Structure-based optimization of indoline-containing compounds as second generation inhibitors of NF-κB-inducing kinase (NIK)

Jing Cheng, Ziqin Yan + Show 7 more

https://doi.org/10.1016/j.molstruc.2023.136755

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Journal: Journal of Molecular Structure

Publication Date: Oct 1, 2023

Affiliation: Shanghai Institute of Materia Medica, University of Chinese Academy of Sciences, Harbin Institute of Technology, Nanjing University of Chinese Medicine, Zhengzhou University

#NF-κB-inducing Kinase #NF-κB-inducing Kinase Inhibitors #Human Metabolic Diseases #Propargylic Alcohol #Immunological Disorders #Series Of Compounds #Primary Hepatocytes #NF-κB2 Pathway #Gene In Hepatocytes #Propargylic Moieties

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Structure-based optimization of indoline-containing compounds as second generation inhibitors of NF-κB-inducing kinase (NIK)

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Structure-based optimization of indoline-containing compounds as second generation inhibitors of NF-κB-inducing kinase (NIK)