Abstract
A new series of (2-(substituted-phenyl) quinoline-4-yl) (3-(substituted phenyl)-5-phenyl-1H-pyrazol-1-yl) methanone derivatives was carried out docking modelling and synthesized. Purity was checked by TLC and chemical structures of synthesized compounds were elucidated by their IR, 1HNMR, MS analysis data. The synthesized compounds were screened for anticancer activity by using cell line MCF-7 (Human breast cancer cell line) correlate with docking modelling.
Highlights
Cancer is an abnormal uncontrollable cell cycle disease characterized by the rapid proliferation of normal cells
Among the various synthetic approaches followed in past research works on quinoline the easiest method i.e. three component cyclocondensation of aromatic aldehyde, purvic acid and aniline in presence of ethanol was followed for synthesis of ester
The synthesized quinoline ester was reacted with hydrazine hydrate to obtain the quinoline carbohydrazide
Summary
Cancer is an abnormal uncontrollable cell cycle disease characterized by the rapid proliferation of normal cells. Chalcone moieties and quinoline play an important role in medicinal chemistry, especially in the identification and development of potential anticancer agents. The multi target approach or hybridization is considered as a promising strategy in drug design and discovery. The conjugation of quinolines with chalcones has been a promising approach to the identification of potential anticancer agents. The quinolone chalcone hybrids with potential anticancer activity have been reviewed. This class of compounds might be helpful for the design, discovery and development of new and potential multi-target anticancer agentsor drug [3]. The development of a new synthetic methodology forsynthesis of compounds containing quinoline and pyrazole continues to be an active and exciting area of research in pharmaceutical chemistry. The pyrazole function is quite stable and has inspired chemist to utilize this stable fragment in bioactive moieties to synthesize new compounds possessing biological activity [6,7]
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