Abstract
Resistance to carbapenem antibiotics in Gram-negative bacteria is due, in part, to expression of a wide spectrum metallo-β-lactamase, which renders the drug inactive. Biphenyl tetrazoles containing 3- n-butyl-1-phenylpyrazole-5-carboxylates or the corresponding 5-ethyl esters were found to inhibit metallo-β-lactamases as well as renal dehydropeptidase I to a lesser extent.
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