Abstract
Scientific interest in cannabinoids increased after the isolation of ∆9-tetrahydrocannabinol (∆9-THC) and prompted a systematic re-evaluation of their use as therapeutical agents. The pharmacological activity of cannabinoids is mediated by two recently identified cannabinoid receptors: the CB1 receptor localized in specific brain areas and the peripheral receptor CB2. In 1992 anandamide, identified as an endogenous ligand for cannabinoid receptors, was shown to share with THC most pharmacological properties in both CNS and peripheral systems1.
Published Version
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