STRUCTURAL REARRANGEMENT OF THE ORGANS OF THE NEUROIMUNOENDOCRINE SYSTEM IN CONDITIONS OF BURN DISEASE

Abstract

The relevance of this study is due to the lack of special studies, the subject of which is the analysis of indicators of endogenous intoxication and structural changes in the histohematological barriers of the organs of the neuroimunoendocrine system in burn disease under conditions of its treatment by infusion of colloidal hyperosmolar solutions. It was found that changes in the permeability of the vascular wall and death of endothelial cells are of particular importance in the development of morphological changes in the adenohypophysis, adrenal cortex and thymus, which at the final stage of these reactions causes the appearance of intraorganic edema and hemorrhage characteristic of burn injury. It can be argued that there is a specific, but common for all studied organs, mechanism of transformation of histohematogenous barriers, which consists in the formation, under the influence of Lactoprotein-C, of a structured, branched, membrane-like complex in a certain way. Its components provide not only strengthening of the vascular wall, but also the isolation of cell clusters. So, the data obtained indicate not the restoration of the structure of histohematogenous barriers, but their structural transformation, which leads to the appearance of a new formation - a membranelike complex, which effectively provides the necessary barrier function. The leading factor of damage to histohematogenous barriers in the studied organs in burn disease is a wide range of morphofunctional changes in the vascular endothelium, which cause the formation of through transmural defects in the wall of blood vessels and the corresponding intraorgan intercellular expansions, the marker of which is the electron-dense Lactoprotein-C. Lactoprotein-C and HAES-LX-5% under conditions of burn disease develop cyto- and angioprotective effects, inhibit the development of hemorrhages, edema, prevent alteration of cells of the adenohypophysis, adrenal cortex and thymus and promote organ repair. Lactoprotein-C is characterized by the first described membrane-plastic property, which ensures the implementation of a specific mechanism of structural transformation of histohematogenous barriers, namely, the creation of a branched membrane-like complex.