Abstract
Transporters have critical biomedical significance due to their fundamental biological role as cellular gatekeepers, and a large and growing collection of transporters has been shown to employ the elevator transport mechanism. Elevator transporters operate by sliding a transport domain up and down across a stationary scaffold domain, and common structural motifs (e.g., reentrant helical hairpins) have frequently been observed in these transport domains. Conservation of structure over evolutionary time is known to far exceed conservation of sequence and even topology and is considered the best and only means available to establish distant evolutionary relationships.
Published Version
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