Abstract
Two bifunctional enzymes, MtmGIV and MtmC, cooperate in the biosynthesis and positioning of two sugars, D-olivose and D-mycarose, of the anticancer antibiotic mithramycin. Hypothesizing a formation of a multifunctional enzyme complex, we started to investigate their interaction with each other using X-ray crystallography of the involved proteins and substrates. We expect to gain further insight in the protein-protein interactions of this complex, the biochemical mechanisms of the reactions, and the substrate channeling.
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