Abstract
Riboswitches are structured elements found in the 5′-untranslated regions of mRNAs that directly bind a small molecule to regulate gene expression in a cis-fashion. These riboregulatory elements typically consist of two domains: an aptamer domain that binds a cellular metabolite and an expression platform that directs expression of the mRNA. Our laboratory is primarily focused upon understanding the three-dimensional structures of these mRNA elements in complex with their effector ligand and how this binding event leads to regulatory control.
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