Structural, cytotoxicity and molecular docking studies of some quinoline schiff bases and their Pd(II), Mn(II) and Ru(II) complexes

Abstract

Mononuclear Pd(II), Mn(II) and Ru(II) complexes have been synthesized from neutral bidentate ligands 1,5-dimethyl-2-phenyl-4-((quinolin-3-ylmethylene)amino)-1,2-dihydro-3H-pyrazol-3-one(QuAP), and 4-((2,6-dimethoxyquinolin-3-yl)methyleneamino)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one (MeOQuAP) respectively. The structures of the isolated products are proposed by the elemental analyses, IR, UV–Vis., 1H NMR, 13C NMR, EPR, Mass and thermogravimetric analysis. The ligands are crystallized in monoclinic crystal lattice with space group P2(1)/c, established by SXRD and their configuration is compared with optimized geometrical parameter by B3LYP with Lanl2DZ basis set. The biological activity of the complexes have been evaluated by examining their apoptotic effect on MCF-7 cells using ethidium bromide (EB) and acridine orange (AO) double stain. Molecular interaction analysis was also performed with Glide-XP implemented in maestro to find the possible amino acid interactions of phosphoinositide 3-kinase receptor. Fluorescence microscopic observation indicated that Ru(II) and Pd(II) complexes can induce apoptosis of MCF-7 cells.