Abstract
Proteins containing low complexity sequence domains harbor mutations genetically linked to neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontal temporal dementia (FTD). Not much is known about the structures these protein domains adopt functionally and what role the mutations play in causing disease. One key protein with mutations present in the low complexity domain (LCD) is T-cell restricted intracellular antigen-1 (TIA1), which forms fibril-like structures that are usually associated with disease.
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