Abstract
HIV-1 Reverse Transcriptase (RT) is a multi-functional enzyme responsible for the viral DNA polymerase and ribonuclease activities required for viral replication. RT is encoded as a 66 kDa polypeptide in the Gag-Pol polyprotein and matured to form a heterodimer composed of 66 kDa (p66) and 51 kDa (p51) subunits. The maturation process of RT is believed to entail dimerization of p66 subunits, followed by cleavage of the C-terminal ribonuclease H domain (RNH) in one of the p66 subunits by viral protease (PR), yielding the p51 subunit within the mature heterodimer.
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