Abstract
Super-relaxation (SRX) is a state of muscle thick filaments in which ATP turnover by myosin is much slower than that of myosin II in solution. This inhibited state, in equilibrium with a faster, disordered-relaxed state (DRX), is ubiquitous across muscle types and species. It is thought to be fundamental to muscle function, acting as a mechanism for switching off energy-consuming myosin motors when they are not being used. The structural basis of super-relaxation is usually taken to be a motif formed by myosin in which the two heads interact with each other and with the proximal tail, forming an interacting-heads motif (IHM), which switches the heads off.
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