Abstract
Inactivation of the tumor suppressor p53 by oncoprotein MDM2 overexpressed in cancer cells promotes tumor growth. The peptides whose sequence mimic the MDM2-binding region within the intrinsically disordered region of p53 reportedly restore the anti-tumor activities of p53. We previously obtained the 12-mer peptide MIP, which has a higher affinity to MDM2 than the known peptides, such as p53 peptide and DI. MIP exhibits higher potency to prevent tumor cell growth. Here, we determined the NMR structure of the MIP:MDM2 complex.
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