Abstract
In the absence of any surfactants, organic solvents or template-directing reagents, the strontium substituted hydroxyapatite (SrHAp) microspheres with hierarchically mesoporous structures and 1.17–5.60mol.% of Sr substitution were successfully fabricated via hydrothermal method. The morphology observation showed that the fabricated SrHAp porous microspheres in diameters of 50–65μm were assembled by two-dimensional single-crystal nano-sheets with 30–70nm in thickness, and up to 3μm in width and length. The ionic extracts of SrHAp porous microspheres promoted the proliferation, osteogenic differentiation and angiogenic factor expression of human osteoblast-like cells (MG-63), and the microspheres with 3.22mol.% of Sr substitution showed the best potentially therapeutic applications in bone regeneration field. In addition, the novel 3D architectures of SrHAp resulted in favorable drug loading and sustained release properties. Our study indicated that the fabricated multifunctional SrHAp porous microspheres might be a potential candidate as bioactive bone-regeneration and drug-delivery material.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
