Strong ion gap compared with liver and kidney function in the application of paraquat poisoning

Abstract

Objective To compare the strong ion gap (SIG) and liver and kidney function index predicting the prognosis of acute paraquat poisoning patients. Methods Retrospective study with a total of 148 cases from 2006 to 2013 who were diagnosed by paraquat poisoning, according to the prognosis they are divided into survival group and death group. Compared with the early SIG, ALT, AST, Cr, BUN index level to analyze with the odds ratio (ORs) and established ROC curve to conform which is more effective on the prognosis of patients with paraquat poisoning. Results The abnormal index of glutamic pyruvic transaminase (ALT) (χ2 =10.257, P =0.001) , glutamic oxalacetic transaminase (AST) (χ2 = 9.109, P =0.003) , creatinine (Cr) (χ2 =10.257, P =0.021) , blood urea nitrogen (BUN) (χ2 = 10.257, P <0.01) indicated a higher risk of death than the normal index, SIG showed higher ORs for fatality than ALT, AST, Cr, BUN (P <0.05) . In the ROC curve, the area under the curve of the SIG, ALT, AST, Cr, BUN on the prognosis of fatality were 0.822, 0.708, 0.724, 0.603, 0.625. Conclusions With early SIG and ALT, AST, Cr, BUN level increased, the risk of death will increase in paraquat poisoning patients, and SIG is a more effective marker than index of kidney and liver function on the prognosis of death. Key words: Paraquat; Poisoning; Strong ion gap; Liver function; Kidney function; Survival; Death; Prognosis