Abstract

The relationship between iodine intake and development of thyroid diseases shows a U-shaped curve with an increase of risk in both deficient and excessive iodine intakes. Our aim was to investigate the relationship between iodine intake and thyroid cancer in patients with thyroid nodules in an iodine-replete area. Retrospective analysis of 1170 patients with thyroid nodules was performed. Urinary iodine concentration (UIC) was measured by inductively-coupled plasma mass spectrometry. Predictive factors for thyroid cancer were evaluated using multivariate logistic regression models. The median UIC in all patients with thyroid nodules was 360μg/L (range from 4 to 9631μg/L). More than half of the patients (650/1170, 56%) belonged to the category of excessive iodine intake (UIC≥300μg/L) according to WHO iodine recommendations. Patients with thyroid cancer were more likely to be distributed in UIC<300μg/L and in UIC≥2500μg/L than those with benign thyroid nodules. Male gender (OR 1.528, p=0.028) and UIC were independent predictors for thyroid cancer. The multivariate-adjusted OR (95% CI) in the relatively low (UIC<300μg/L) and extremely excessive (UIC≥2500μg/L) iodine intake groups for thyroid cancer were 1.519 (1.099-2.098) and 1.874 (1.094-3.208), respectively, compared to the other iodine intake group (300-2499μg/L). Male gender and UIC were independent predictors of thyroid cancer in patients with thyroid nodules. This study suggests that relatively low and extremely excessive iodine intakes are associated with thyroid cancer in an iodine-replete area.

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