Abstract
Strong antibacterial polydopamine (PDA) coatings prepared by a facile shaking-assisted method is reported for the first time. It was found that a minor modification made to the conventional synthesis procedure of PDA coatings, viz. replacing the static solution condition with a shaking solution condition by using a mechanical shaker, can produce the roughened polydopamine (rPDA) coatings at different substrates, e.g., glass, stainless steel, plastic, and gauze. The resulting rPDA coatings were characterized with Raman spectrum, zeta-potential analysis and contact angle measurement. The antibacterial activity of the rPDA coatings was evaluated by a shake flask test with gram-positive Staphylococcus aureus, and gram-negative Escherichia coli and Pseudomonas aeruginosa as bacteria models. Testing results revealed that, in the absence of any other antibacterial agents, the rPDA coatings exhibited remarkably enhanced antibacterial activities. In addition, such enhanced antibacterial activities of the rPDA coatings were found to be unimpaired by steam sterilization treatments.
Highlights
Nowadays interest in implantation of medical devices has continued to accelerate
The PDA coatings produced under static solution conditions or 100-rpm-shaking conditions are denoted as the sPDA coatings
This study has demonstrated that a shaking condition applied to the self-polymerization of dopamine in alkaline solution can facilitate the formation of the roughened polydopamine (rPDA) coatings
Summary
Nowadays interest in implantation of medical devices has continued to accelerate. bacterial infection at the site of implanted medical devices has become a serious ongoing problem[1,2,3,4]. Contact-active antibacterial coatings have attracted increasing attention[10,11,12,13,14,15]. We report the shaking-assisted one-step preparation of strong contact-active antibacterial PDA coatings without using any other antibacterial reagents for the first time. In the absence of any other antibacterial reagents, the rPDA coatings can exhibit enhanced contact-active antibacterial activities towards gram-positive S. aureus, and gram-negative E. coli and Pseudomonas aeruginosa (P. aeruginosa). Such strong antibacterial performances are unimpaired by steam sterilization treatment that is a necessary procedure for implantation
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