Abstract
The stress-induced hyperthermia (SIH) response is the transient change in body temperature in response to acute stress. This body temperature response is part of the autonomic stress response which also results in tachycardia and an increased blood pressure. So far, a SIH response has been found in a variety of species (including rodents, baboons, turtles, pigs, impalas and chimpanzees), and there are indications that stress exposure alters body temperature in humans. This review aims to assess the translational potential and the different aspects of the body temperature reaction in response to stress. If stress-induced temperature changes are consistent across species, the SIH paradigm may be employed in preclinical and clinical setups and provide a tool to examine the pharmacological, genetic and mechanistic background of stress at both the preclinical and the clinical level.
Highlights
Animal models have significantly aided in establishing the biological basis of stress-related psychiatric disorders including anxiety disorders and depression [1]
The stress-induced hyperthermia (SIH) response is a relatively short-lasting rise in body temperature in response to stress which has been reported in rodents, baboons, sheep, impalas and chimpanzees
We showed that the classical benzodiazepine diazepam but not the prostaglandin-blocking aspirin attenuated the SIH response in rodents, whereas aspirin but not diazepam greatly reduced LPS- and IL-1 induced fever states, suggesting that stress-induced hyperthermia and infectioninduced fever are two distinct processes [19]
Summary
Animal models have significantly aided in establishing the biological basis of stress-related psychiatric disorders including anxiety disorders and depression [1]. The stress-induced hyperthermia (SIH) response is a relatively short-lasting rise in body temperature in response to stress which has been reported in rodents, baboons, sheep, impalas and chimpanzees (for review see [2]). The SIH response does not model any specific psychiatric condition, this response may be useful as a read-out parameter of stress. It can be studied at the preclinical and clinical level in different stressful experimental setups and may serve as an animal-tohuman stress-related parameter. 1874-1436/10 preclinical species, the SIH paradigm may be relevant for research into human stress-related disorders, including the assessment of putative stress-attenuating properties of drugs
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