Abstract
Mammalians have recognition-behavioral stress-coping neuronal module system followed by some humoral glycolipids. A sulfated Galbeta1-4GlcNAc-lipid promotes the serotonergic module regulating the emotional behaviors for not-wasting the physical strength; GalNAcalpha1-3GalNAc-lipid promotes the adrenergic module inducing the behaviors escaping from the uneasy situation, and sulfated Fucalpha1-2Gal-lipid protects the cholinergic module keeping the stressor-memory from the ischemia-stress. Mouse given bathing recognizes the stressors to be coped with in the treatment. We previously observed mouse given CO2-microbubble-bathing increased the behavior escaping from the bathing situation. Mouse given CO2-microbubble-bathing would recognize the other stressors to be coped with in the treatment. We examined stress-coping glycolipids produced by mice given controlled bathing treatments, and got the following results. A sulfated Galbeta1-4GlcNAc-lipid production was increased by the acidic bathing condition and the dissolved CO2, GalNAcalpha1-3GalNAc-lipid production was increased by the dissolved CO2, and sulfated Fucalpha1-2Gal-lipid production was increased by the acidic bathing condition. We understood the mice treated with CO2-microbubble-bathing would recognize the acidic bathing condition and the dissolved CO2, but not the microbubble, as the other stressors to be coped.
Highlights
We previously found mouse given CO2-microbubble-bathing showed the behavior escaping from the bathing situation, more than mouse given bathing did [1]
One day a er this, 6 mice were treated with the tap-water bathing for 3 min (Bathing group: B group) as Positive Control, another 6 mice were treated with the tap-water bathing in pH 5 bathing condition for 3 min, another 6 mice were treated with the tap-water bathing generated air-microbubble for 3 min (Microbubble-bathing group: MB group), and the other 6 mice were treated with the tap-water bathing generated CO2-microbubble for 3 min (CO2-microbubble-bathing group: CM group)
A sG1-4GN is produced for maintaining the physical strength, GN1-3GN is produced for inducing the behaviors escaping from the uneasy situation, and sF1-2G is produced for keeping the stressor-memory
Summary
We have investigated mammalian recognitionbehavioral stress-coping system. We previously found mouse given CO2-microbubble-bathing showed the behavior escaping from the bathing situation, more than mouse given bathing did [1]. We found some humoral glycolipids following the recognition-behavioral stresscoping modules. A sulfated Galbeta1-4GlcNAc-lipid (3-O-Sulfo-Beta-D-Galactosyl-(1->4)-N-Acetyl-Beta-DGlucosamine-lipid; sG1-4GN) promotes the serotonergic module regulating the emotional behaviors for not-wasting the physical strength [3, 4]. A GalNAcalpha1-3GalNAc-lipid (GalNAcalpha1->3GalNAc-lipid; GN1-3GN) promotes the adrenergic module inducing the behaviors escaping from the uneasy situation [5, 6]. Mammalians produce the stress-coping glycolipids corresponding to the stressors. Mouse given bathing recognizes the stressors to be coped in the treatment. We hypothesized mouse given CO2-microbubble-bathing would recognize the other stressors to be coped with in the treatment. We examine the stress-coping glycolipids produced by mice given controlled bathing treatments
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