Abstract

Skeletal muscle strength is reduced in patients with schizophrenia, contributing to their impaired physical health, functional performance, and potentially mental health challenges. Although short-term training programs have shown promising results, improving muscle strength and functional performance, it is unknown how exercise can be successfully integrated into the long-term clinical care of outpatients with schizophrenia. To investigate effects of strength training with adherence support in a collaborative care model. We randomized 28 men and 20 women (mean±SD, 35±11years) to leg press maximal strength training (MST) with 4 sets at 90% of one repetition maximum (1RM) 2×week, facilitated by municipal service and professional supervision (TG), or a control group (CG). The TG increased scaled leg press 1RM (0-3months: 19%; 0-6months: 31%, 0-12months: 40%, all p<.001, and 3-12months: 18%, p<.05) and power (0-3months, 11%; 0-6months: 22%, 0-12months: 26%, all p<.001, and 3-12months: 13%, p<.05) throughout the 1-year period compared to the CG. The increased muscle strength was accompanied by improved sit-to-stand performance (20%) after 12months (p<.001). Both groups also exhibited within-group improvements in walking work efficiency after 6months (TG: 13%; CG: 23%) and 1year (TG: 11%; CG: 21%, p<.01-0.05), but with no evident differences between the groups. Stair climbing performance remained unchanged. Our results reveal that strength training can successfully be integrated as a part of long-term clinical care of outpatients with schizophrenia, contributing to improved functional performance.

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